Hamas’ attack on Israel has claimed the lives of at least 22 Americans.

A spokesperson for the United States Department of State confirmed on Wednesday that at least 22 Americans had been killed in Hamas’ terrorist strike in Israel.

“We extend our deepest condolences to the victims and to the families of all those affected,” the spokesperson said.

National Security Council Adviser Jake Sullivan told reporters on Tuesday that at least 20 Americans are missing and it is unknown how many Americans are being kept captive.

On Tuesday, Vice President Biden gave a public statement in which he reaffirmed American support for Israel.

“This was an act of sheer evil. More than 1,000 civilians slaughtered. Not just killed. Slaughtered in Israel,” Biden said, “Among them at least 14 American citizens killed. Parents butchered using their bodies to try to protect their children. Stomach-churning reports of babies being killed. Entire families slang. Young people massacred while attending a music festival to celebrate peace. To celebrate peace. Women raped, assaulted, paraded as trophies.”

Biden advised U.S. citizens who want to leave Israel to do so through commercial flight or ground transportation hours before major airlines such as Delta, American, and United began canceling flights to and from Israel.

“For American citizens who are currently in Israel, the State Department is providing consular assistance as well as updated security alerts. For those who desire to leave, commercial flights and ground options are still available,” Biden wrote in a Monday statement. “Please also take sensible precautions in the days ahead and follow the guidance of local authorities.”

On Friday, Hamas entered Israel and began a bloody massacre and hostage situation.